Publications

WASp triggers mechanosensitive actin patches to facilitate immune cell migration in dense tissues
F. Gaertner, P. Reis-Rodrigues, I. de Vries, M. Hons, J. Aguilera, M. Riedl, A.F. Leithner, S. Tasciyan, A. Kopf, J. Merrin, V. Zheden, W. Kaufmann, R. Hauschild, M.K. Sixt, Developmental Cell 57 (2022) 47–62.e9.
LibreCat: https://research-explorer.app.ist.ac.at/record/10703
DOI: 10.1016/j.devcel.2021.11.024
PMID: 34919802

Shape and function of interstitial chemokine CCL21 gradients are independent of heparan sulfates produced by lymphatic endothelium
K. Vaahtomeri, C. Moussion, R. Hauschild, M.K. Sixt, Frontiers in Immunology 12 (2021).
LibreCat: https://research-explorer.app.ist.ac.at/record/9259
DOI: 10.3389/fimmu.2021.630002
PMID: 33717158

Engaging the front wheels to drive through fibrous terrain
F.R. Gärtner, M.K. Sixt, Developmental Cell 56 (2021) 723–725.
LibreCat: https://research-explorer.app.ist.ac.at/record/9294
DOI: 10.1016/j.devcel.2021.03.002

Multi-tier mechanics control stromal adaptations in swelling lymph nodes
F.P. Assen, M. Hons, R. Hauschild, S. Shamipour, J. Abe, W. Kaufmann, T. Costanzo, G. Krens, M. Brown, B. Ludewig, S. Hippenmeyer, J.V. Stein, C.-P.J. Heisenberg, E.B. Hannezo, S.A. Luther, M.K. Sixt, BioRxiv (n.d.).
LibreCat: https://research-explorer.app.ist.ac.at/record/9794
DOI: 10.1101/2021.07.28.454217

Sequential and switchable patterning for studying cellular processes under spatiotemporal control
T. Zisis, J. Schwarz, M. Balles, M. Kretschmer, M. Nemethova, R.P. Chait, R. Hauschild, J. Lange, C.C. Guet, M.K. Sixt, S. Zahler, ACS Applied Materials and Interfaces 13 (2021) 35545–35560.
LibreCat: https://research-explorer.app.ist.ac.at/record/9822
DOI: 10.1021/acsami.1c09850
PMID: 34283577

Pathogenic Escherichia coli hijack the host immune response
K. Tomasek, Pathogenic Escherichia Coli Hijack the Host Immune Response, IST Austria, 2021.
LibreCat: https://research-explorer.app.ist.ac.at/record/10307
DOI: 10.15479/at:ista:10307

Type 1 piliated uropathogenic Escherichia coli hijack the host immune response by binding to C
K. Tomasek, A.F. Leithner, I. Glatzová, M.S. Lukesch, C.C. Guet, M.K. Sixt, BioRxiv (n.d.).
LibreCat: https://research-explorer.app.ist.ac.at/record/10316
DOI: 10.1101/2021.10.18.464770

Dendritic cell actin dynamics control contact duration and priming efficiency at the immunological synapse
A.F. Leithner, L. Altenburger, R. Hauschild, F.P. Assen, K. Rottner, S. TEB, A. Diz-Muñoz, J. Stein, M.K. Sixt, Journal of Cell Biology 220 (2021).
LibreCat: https://research-explorer.app.ist.ac.at/record/9094
DOI: 10.1083/jcb.202006081
PMID: 33533935

Microtubules control cellular shape and coherence in amoeboid migrating cells
A. Kopf, J. Renkawitz, R. Hauschild, I. Girkontaite, K. Tedford, J. Merrin, O. Thorn-Seshold, D. Trauner, H. Häcker, K.D. Fischer, E. Kiermaier, M.K. Sixt, The Journal of Cell Biology 219 (2020).
LibreCat: https://research-explorer.app.ist.ac.at/record/7875
DOI: 10.1083/jcb.201907154
PMID: 32379884

T cells: Bridge-and-channel commute to the white pulp
M.K. Sixt, T. Lämmermann, Immunity 52 (2020) 721–723.
LibreCat: https://research-explorer.app.ist.ac.at/record/7876
DOI: 10.1016/j.immuni.2020.04.020

Cellular locomotion using environmental topography
A. REVERSAT, F.R. Gärtner, J. Merrin, J.A. Stopp, S. Tasciyan, J.L. Aguilera Servin, I. de Vries, R. Hauschild, M. Hons, M. Piel, A. Callan-Jones, R. Voituriez, M.K. Sixt, Nature 582 (2020) 582–585.
LibreCat: https://research-explorer.app.ist.ac.at/record/7885
DOI: 10.1038/s41586-020-2283-z

Loss of Ena/VASP interferes with lamellipodium architecture, motility and integrin-dependent adhesion
J. Damiano-Guercio, L. Kurzawa, J. Müller, G.A. Dimchev, M. Schaks, M. Nemethova, T. Pokrant, S. Brühmann, J. Linkner, L. Blanchoin, M.K. Sixt, K. Rottner, J. Faix, ELife 9 (2020).
LibreCat: https://research-explorer.app.ist.ac.at/record/7909
DOI: 10.7554/eLife.55351

The cytoskeletal regulator HEM1 governs B cell development and prevents autoimmunity
E. Salzer, S. Zoghi, M.G. Kiss, F. Kage, C. Rashkova, S. Stahnke, M. Haimel, R. Platzer, M. Caldera, R.C. Ardy, B. Hoeger, J. Block, D. Medgyesi, C. Sin, S. Shahkarami, R. Kain, V. Ziaee, P. Hammerl, C. Bock, J. Menche, L. Dupré, J.B. Huppa, M.K. Sixt, A. Lomakin, K. Rottner, C.J. Binder, T.E.B. Stradal, N. Rezaei, K. Boztug, Science Immunology 5 (2020).
LibreCat: https://research-explorer.app.ist.ac.at/record/8132
DOI: 10.1126/sciimmunol.abc3979
PMID: 32646852

Phytohormone cytokinin guides microtubule dynamics during cell progression from proliferative to differentiated stage
J.C. Montesinos López, A. Abuzeineh, A. Kopf, A. Juanes Garcia, K. Ötvös, J. Petrásek, M.K. Sixt, E. Benková, The Embo Journal 39 (2020).
LibreCat: https://research-explorer.app.ist.ac.at/record/8142
DOI: 10.15252/embj.2019104238
PMID: 32667089

Partial loss of actin nucleator actin-related protein 2/3 activity triggers blebbing in primary T lymphocytes
P. Obeidy, L.A. Ju, S.H. Oehlers, N.S. Zulkhernain, Q. Lee, J.L. Galeano Niño, R.Y.Q. Kwan, S. Tikoo, L.L. Cavanagh, P. Mrass, A.J.L. Cook, S.P. Jackson, M. Biro, B. Roediger, M.K. Sixt, W. Weninger, Immunology and Cell Biology 98 (2020) 93–113.
LibreCat: https://research-explorer.app.ist.ac.at/record/7234
DOI: 10.1111/imcb.12304
PMID: 31698518

Modeling adhesion-independent cell migration
G. Jankowiak, D. Peurichard, A. REVERSAT, C. Schmeiser, M.K. Sixt, Mathematical Models and Methods in Applied Sciences 30 (2020) 513–537.
LibreCat: https://research-explorer.app.ist.ac.at/record/7623
DOI: 10.1142/S021820252050013X
arXiv: 1903.09426

Zena Werb (1945-2020): Cell biology in context
M.K. Sixt, A. Huttenlocher, The Journal of Cell Biology 219 (2020).
LibreCat: https://research-explorer.app.ist.ac.at/record/8190
DOI: 10.1083/jcb.202007029

Gut homeostasis: Active migration of intestinal epithelial cells in tissue renewal
A. Kopf, M.K. Sixt, Current Biology 29 (2019) 91–93.
LibreCat: https://research-explorer.app.ist.ac.at/record/6979
DOI: 10.1016/j.cub.2019.08.068
PMID: 31639357

Mechanisms of 3D cell migration
K. Yamada, M.K. Sixt, Nature Reviews Molecular Cell Biology 20 (2019) 738–752.
LibreCat: https://research-explorer.app.ist.ac.at/record/7009
DOI: 10.1038/s41580-019-0172-9
PMID: 31582855

Persistent and polarized global actin flow is essential for directionality during cell migration
L. Yolland, M. Burki, S. Marcotti, A. Luchici, F.N. Kenny, J.R. Davis, E. Serna-Morales, J. Müller, M.K. Sixt, A. Davidson, W. Wood, L.J. Schumacher, R.G. Endres, M. Miodownik, B.M. Stramer, Nature Cell Biology 21 (2019) 1370–1381.
LibreCat: https://research-explorer.app.ist.ac.at/record/7105
DOI: 10.1038/s41556-019-0411-5
PMID: 31685997

The implication of cytoskeletal dynamics on leukocyte migration
A. Kopf, The Implication of Cytoskeletal Dynamics on Leukocyte Migration, IST Austria, 2019.
LibreCat: https://research-explorer.app.ist.ac.at/record/6891
DOI: 10.15479/AT:ISTA:6891

Nuclear positioning facilitates amoeboid migration along the path of least resistance
J. Renkawitz, A. Kopf, J.A. Stopp, I. de Vries, M.K. Driscoll, J. Merrin, R. Hauschild, E.S. Welf, G. Danuser, R. Fiolka, M.K. Sixt, Nature 568 (2019) 546–550.
LibreCat: https://research-explorer.app.ist.ac.at/record/6328
DOI: 10.1038/s41586-019-1087-5
PMID: 30944468

The neural crest pitches in to remove apoptotic debris
A. Kopf, M.K. Sixt, Cell 179 (2019) 51–53.
LibreCat: https://research-explorer.app.ist.ac.at/record/6877
DOI: 10.1016/j.cell.2019.08.047
PMID: 31539498

Lymph node mechanics: Deciphering the interplay between stroma contractility, morphology and lymphocyte trafficking
F.P. Assen, Lymph Node Mechanics: Deciphering the Interplay between Stroma Contractility, Morphology and Lymphocyte Trafficking, IST Austria, 2019.
LibreCat: https://research-explorer.app.ist.ac.at/record/6947
DOI: 10.15479/AT:ISTA:6947

A fat lot of good for wound healing
A.M. Casano, M.K. Sixt, Developmental Cell 44 (2018) 405–406.
LibreCat: https://research-explorer.app.ist.ac.at/record/318
DOI: 10.1016/j.devcel.2018.02.009
PMID: 29486189

The Rho regulator Myosin IXb enables nonlymphoid tissue seeding of protective C+T cells
F. Moalli, X. Ficht, P. Germann, M. Vladymyrov, B. Stolp, I. de Vries, R. Lyck, J. Balmer, A. Fiocchi, M. Kreutzfeldt, D. Merkler, M. Iannacone, A. Ariga, M.H. Stoffel, J. Sharpe, M. Bähler, M.K. Sixt, A. Diz-Muñoz, J.V. Stein, The Journal of Experimental Medicine 2015 (2018) 1869–1890.
LibreCat: https://research-explorer.app.ist.ac.at/record/6497
DOI: 10.1084/jem.20170896

IgM’s exit route
A. REVERSAT, M.K. Sixt, Journal of Experimental Medicine 215 (2018) 2959–2961.
LibreCat: https://research-explorer.app.ist.ac.at/record/5672
DOI: 10.1084/jem.20181934

Mechanistic description of spatial processes using integrative modelling of noise-corrupted imaging data
S. Hross, F.J. Theis, M.K. Sixt, J. Hasenauer, Journal of the Royal Society Interface 15 (2018).
LibreCat: https://research-explorer.app.ist.ac.at/record/5858
DOI: 10.1098/rsif.2018.0600

The cell sets the tone
J.H. Alanko, M.K. Sixt, ELife 7 (2018).
LibreCat: https://research-explorer.app.ist.ac.at/record/5861
DOI: 10.7554/eLife.37888

On the relation between filament density, force generation, and protrusion rate in mesenchymal cell motility
S. Dolati, F. Kage, J. Mueller, M. Müsken, M. Kirchner, G. Dittmar, M.K. Sixt, K. Rottner, M. Falcke, Molecular Biology of the Cell 29 (2018) 2674–2686.
LibreCat: https://research-explorer.app.ist.ac.at/record/5992
DOI: 10.1091/mbc.e18-02-0082
PMID: 30156465

Micro-engineered cpillar forestsd to study cell migration in complex but controlled 3D environments
J. Renkawitz, A. REVERSAT, A.F. Leithner, J. Merrin, M.K. Sixt, in:, Methods in Cell Biology, Academic Press, 2018, pp. 79–91.
LibreCat: https://research-explorer.app.ist.ac.at/record/153
DOI: 10.1016/bs.mcb.2018.07.004
PMID: 30165964

Fast and efficient genetic engineering of hematopoietic precursor cells for the study of dendritic cell migration
A.F. Leithner, J. Renkawitz, I. de Vries, R. Hauschild, H. Haecker, M.K. Sixt, European Journal of Immunology 48 (2018) 1074–1077.
LibreCat: https://research-explorer.app.ist.ac.at/record/437
DOI: 10.1002/eji.201747358

Lymphatic exosomes promote dendritic cell migration along guidance cues
M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.
LibreCat: https://research-explorer.app.ist.ac.at/record/275
DOI: 10.1083/jcb.201612051
PMID: 29650776

Branched actin networks in dendritic cell biology
A.F. Leithner, Branched Actin Networks in Dendritic Cell Biology, IST Austria, 2018.
LibreCat: https://research-explorer.app.ist.ac.at/record/323
DOI: 10.15479/AT:ISTA:th_998

Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.
LibreCat: https://research-explorer.app.ist.ac.at/record/15
DOI: 10.1038/s41590-018-0109-z
PMID: 29777221

Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
M. Brown, F.P. Assen, A.F. Leithner, J. Abe, H. Schachner, G. Asfour, Z. Bagó Horváth, J. Stein, P. Uhrin, M.K. Sixt, D. Kerjaschki, Science 359 (2018) 1408–1411.
LibreCat: https://research-explorer.app.ist.ac.at/record/402
DOI: 10.1126/science.aal3662
PMID: 29567714

FMNL formins boost lamellipodial force generation
F. Kage, M. Winterhoff, V. Dimchev, J. Müller, T. Thalheim, A. Freise, S. Brühmann, J. Kollasser, J. Block, G.A. Dimchev, M. Geyer, H. Schnittler, C. Brakebusch, T. Stradal, M. Carlier, M.K. Sixt, J. Käs, J. Faix, K. Rottner, Nature Communications 8 (2017).
LibreCat: https://research-explorer.app.ist.ac.at/record/659
DOI: 10.1038/ncomms14832

Multiple roles of filopodial dynamics in particle capture and phagocytosis and phenotypes of Cd and Myo10 deletion
M. Horsthemke, A. Bachg, K. Groll, S. Moyzio, B. Müther, S. Hemkemeyer, R. Wedlich Söldner, M.K. Sixt, S. Tacke, M. Bähler, P. Hanley, Journal of Biological Chemistry 292 (2017) 7258–7273.
LibreCat: https://research-explorer.app.ist.ac.at/record/668
DOI: 10.1074/jbc.M116.766923

Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia
K. Vaahtomeri, M. Brown, R. Hauschild, I. de Vries, A.F. Leithner, M. Mehling, W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.
LibreCat: https://research-explorer.app.ist.ac.at/record/672
DOI: 10.1016/j.celrep.2017.04.027

Dendritic cells interpret haptotactic chemokine gradients in a manner governed by signal to noise ratio and dependent on GRK6
J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. de Vries, A.F. Leithner, A. REVERSAT, J. Merrin, T. Tarrant, M.T. Bollenbach, M.K. Sixt, Current Biology 27 (2017) 1314–1325.
LibreCat: https://research-explorer.app.ist.ac.at/record/674
DOI: 10.1016/j.cub.2017.04.004

The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.
LibreCat: https://research-explorer.app.ist.ac.at/record/679
DOI: 10.1172/JCI80631
PMID: 28504646

A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3 and adhesion plasticity
A. Veß, U. Blache, L. Leitner, A. Kurz, A. Ehrenpfordt, M.K. Sixt, G. Posern, Journal of Cell Science 130 (2017) 2172–2184.
LibreCat: https://research-explorer.app.ist.ac.at/record/694
DOI: 10.1242/jcs.200899
PMID: 28515231

Cytokinesis in vertebrate cells initiates by contraction of an equatorial actomyosin network composed of randomly oriented filaments
F. Spira, S. Cuylen Haering, S. Mehta, M. Samwer, A. REVERSAT, A. Verma, R. Oldenbourg, M.K. Sixt, D. Gerlich, ELife 6 (2017).
LibreCat: https://research-explorer.app.ist.ac.at/record/569
DOI: 10.7554/eLife.30867

Migrating platelets are mechano scavengers that collect and bundle bacteria
F.R. Gärtner, Z. Ahmad, G. Rosenberger, S. Fan, L. Nicolai, B. Busch, G. Yavuz, M. Luckner, H. Ishikawa Ankerhold, R. Hennel, A. Benechet, M. Lorenz, S. Chandraratne, I. Schubert, S. Helmer, B. Striednig, K. Stark, M. Janko, R. Böttcher, A. Verschoor, C. Leon, C. Gachet, T. Gudermann, M. Mederos Y Schnitzler, Z. Pincus, M. Iannacone, R. Haas, G. Wanner, K. Lauber, M.K. Sixt, S. Massberg, Cell Press 171 (2017) 1368–1382.
LibreCat: https://research-explorer.app.ist.ac.at/record/571
DOI: 10.1016/j.cell.2017.11.001

Load adaptation of lamellipodial actin networks
J. Mueller, G. Szep, M. Nemethova, I. de Vries, A. Lieber, C. Winkler, K. Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017) 188–200.
LibreCat: https://research-explorer.app.ist.ac.at/record/727
DOI: 10.1016/j.cell.2017.07.051

Cell migration: Making the waves
J. Müller, M.K. Sixt, Current Biology 27 (2017) –.
LibreCat: https://research-explorer.app.ist.ac.at/record/1161
DOI: 10.1016/j.cub.2016.11.035

The dynamic cytokine niche
F.P. Assen, M.K. Sixt, Immunity 46 (2017) 519–520.
LibreCat: https://research-explorer.app.ist.ac.at/record/664
DOI: 10.1016/j.immuni.2017.04.006

Quantitative analysis of dendritic cell haptotaxis
J. Schwarz, M.K. Sixt, Methods in Enzymology 570 (2016) 567–581.
LibreCat: https://research-explorer.app.ist.ac.at/record/1597
DOI: 10.1016/bs.mie.2015.11.004
PMID: 26921962

Polysialylation controls dendritic cell trafficking by regulating chemokine recognition
E. Kiermaier, C. Moussion, C. Veldkamp, R. Gerardy  Schahn, I. de Vries, L. Williams, G. Chaffee, A. Phillips, F. Freiberger, R. Imre, D. Taleski, R. Payne, A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. Volkman, M.K. Sixt, Science 351 (2016) 186–190.
LibreCat: https://research-explorer.app.ist.ac.at/record/1599
DOI: 10.1126/science.aad0512
PMID: 26657283

Formin’ a nuclear protection
J. Renkawitz, M.K. Sixt, Cell 167 (2016) 1448–1449.
LibreCat: https://research-explorer.app.ist.ac.at/record/1201
DOI: 10.1016/j.cell.2016.11.024

Focal adhesion-independent cell migration
E. Paluch, I. Aspalter, M.K. Sixt, Annual Review of Cell and Developmental Biology 32 (2016) 469–490.
LibreCat: https://research-explorer.app.ist.ac.at/record/1285
DOI: 10.1146/annurev-cellbio-111315-125341

Intralymphatic CCL21 promotes tissue egress of dendritic cells through afferent lymphatic vessels
E. Russo, A. Teijeira, K. Vaahtomeri, A. Willrodt, J. Bloch, M. Nitschké, L. Santambrogio, D. Kerjaschki, M.K. Sixt, C. Halin, Cell Reports 14 (2016) 1723–1734.
LibreCat: https://research-explorer.app.ist.ac.at/record/1490
DOI: 10.1016/j.celrep.2016.01.048

Quantitative analysis of haptotactic cell migration
J. Schwarz, Quantitative Analysis of Haptotactic Cell Migration, IST Austria, 2016.
LibreCat: https://research-explorer.app.ist.ac.at/record/1129

RASGR deficiency causes immunodeficiency with impaired cytoskeletal dynamics
E. Salzer, D. Ça7daf, M. Hons, E. Mace, W. Garncarz, O. Petronczki, R. Platzer, L. Pfajfer, I. Bilic, S. Ban, K. Willmann, M. Mukherjee, V. Supper, H. Hsu, P. Banerjee, P. Sinha, F. Mcclanahan, G. Zlabinger, W. Pickl, J. Gribben, H. Stockinger, K. Bennett, J. Huppa, L. Dupré, Ö. Sanal, U. Jäger, M.K. Sixt, I. Tezcan, J. Orange, K. Boztug, Nature Immunology 17 (2016) 1352–1360.
LibreCat: https://research-explorer.app.ist.ac.at/record/1137
DOI: 10.1038/ni.3575
PMID: 27776107

Heme drives hemolysis-induced susceptibility to infection via disruption of phagocyte functions
R. Martins, J. Maier, A. Gorki, K. Huber, O. Sharif, P. Starkl, S. Saluzzo, F. Quattrone, R. Gawish, K. Lakovits, M. Aichinger, B. Radic Sarikas, C. Lardeau, A. Hladik, A. Korosec, M. Brown, K. Vaahtomeri, M. Duggan, D. Kerjaschki, H. Esterbauer, J. Colinge, S. Eisenbarth, T. Decker, K. Bennett, S. Kubicek, M.K. Sixt, G. Superti Furga, S. Knapp, Nature Immunology 17 (2016) 1361–1372.
LibreCat: https://research-explorer.app.ist.ac.at/record/1142
DOI: 10.1038/ni.3590

A Radical Break Restraining Neutrophil Migration
J. Renkawitz, M.K. Sixt, Developmental Cell 38 (2016) 448–450.
LibreCat: https://research-explorer.app.ist.ac.at/record/1150
DOI: 10.1016/j.devcel.2016.08.017

A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients
J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach, S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).
LibreCat: https://research-explorer.app.ist.ac.at/record/1154
DOI: 10.1038/srep36440

Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
A.F. Leithner, A. Eichner, J. Müller, A. REVERSAT, M. Brown, J. Schwarz, J. Merrin, D. De Gorter, F.K. Schur, J. Bayerl, I. de Vries, S. Wieser, R. Hauschild, F. Lai, M. Moser, D. Kerjaschki, K. Rottner, V. Small, T. Stradal, M.K. Sixt, Nature Cell Biology 18 (2016) 1253–1259.
LibreCat: https://research-explorer.app.ist.ac.at/record/1321
DOI: 10.1038/ncb3426

The serotonin receptor 5-HR regulates the morphology and migratory properties of dendritic cells
K. Holst, D. Guseva, S. Schindler, M.K. Sixt, A. Braun, H. Chopra, O. Pabst, E. Ponimaskin, Journal of Cell Science 128 (2015) 2866–2880.
LibreCat: https://research-explorer.app.ist.ac.at/record/477
DOI: 10.1242/jcs.167999

Actin flows mediate a universal coupling between cell speed and cell persistence
P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M. Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger, M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez, Cell 161 (2015) 374–386.
LibreCat: https://research-explorer.app.ist.ac.at/record/1553
DOI: 10.1016/j.cell.2015.01.056

The lymph node filter revealed
M. Hons, M.K. Sixt, Nature Immunology 16 (2015) 338–340.
LibreCat: https://research-explorer.app.ist.ac.at/record/1560
DOI: 10.1038/ni.3126

A novel Cre recombinase reporter mouse strain facilitates selective and efficient infection of primary immune cells with adenoviral vectors
K. Heger, M. Kober, D. Rieß, C. Drees, I. de Vries, A. Bertossi, A. Roers, M.K. Sixt, M. Schmidt Supprian, European Journal of Immunology 45 (2015) 1614–1620.
LibreCat: https://research-explorer.app.ist.ac.at/record/1561
DOI: 10.1002/eji.201545457

Cell migration and antigen capture are antagonistic processes coupled by myosin II in dendritic cells
M. Chabaud, M. Heuzé, M. Bretou, P. Vargas, P. Maiuri, P. Solanes, M. Maurin, E. Terriac, M. Le Berre, D. Lankar, T. Piolot, R. Adelstein, Y. Zhang, M.K. Sixt, J. Jacobelli, O. Bénichou, R. Voituriez, M. Piel, A. Lennon Duménil, Nature Communications 6 (2015).
LibreCat: https://research-explorer.app.ist.ac.at/record/1575
DOI: 10.1038/ncomms8526

Solution structure of CCL19 and identification of overlapping CC and PSGL-1 binding sites
C. Veldkamp, E. Kiermaier, S. Gabel Eissens, M. Gillitzer, D. Lippner, F. Disilvio, C. Mueller, P. Wantuch, G. Chaffee, M. Famiglietti, D. Zgoba, A. Bailey, Y. Bah, S. Engebretson, D. Graupner, E. Lackner, V. Larosa, T. Medeiros, M. Olson, A. Phillips, H. Pyles, A. Richard, S. Schoeller, B. Touzeau, L. Williams, M.K. Sixt, F. Peterson, Biochemistry 54 (2015) 4163–4166.
LibreCat: https://research-explorer.app.ist.ac.at/record/1618
DOI: 10.1021/acs.biochem.5b00560
PMID: 26115234

Editorial overview: Cell adhesion and migration
M.K. Sixt, E. Raz, Current Opinion in Cell Biology 36 (2015) 4–6.
LibreCat: https://research-explorer.app.ist.ac.at/record/1676
DOI: 10.1016/j.ceb.2015.09.004

Fragmented communication between immune cells: Neutrophils blaze a trail with migratory cues for T cells to follow to sites of infection
E. Kiermaier, M.K. Sixt, Science 349 (2015) 1055–1056.
LibreCat: https://research-explorer.app.ist.ac.at/record/1686
DOI: 10.1126/science.aad0867

Navigating in tissue mazes: Chemoattractant interpretation in complex environments
M. Sarris, M.K. Sixt, Current Opinion in Cell Biology 36 (2015) 93–102.
LibreCat: https://research-explorer.app.ist.ac.at/record/1687
DOI: 10.1016/j.ceb.2015.08.001

Cortical contractility triggers a stochastic switch to fast amoeboid cell motility
V. Ruprecht, S. Wieser, A. Callan Jones, M. Smutny, H. Morita, K. Sako, V. Barone, M. Ritsch Marte, M.K. Sixt, R. Voituriez, C.-P.J. Heisenberg, Cell 160 (2015) 673–685.
LibreCat: https://research-explorer.app.ist.ac.at/record/1537
DOI: 10.1016/j.cell.2015.01.008

Physiology: Relax and come in
M.K. Sixt, K. Vaahtomeri, Nature 514 (2014) 441–442.
LibreCat: https://research-explorer.app.ist.ac.at/record/1877
DOI: 10.1038/514441a

Langerhans cell maturation is accompanied by induction of N-cadherin and the transcriptional regulators of epithelial-mesenchymal transition ZE/2
S. Konradi, N. Yasmin, D. Haslwanter, M. Weber, B. Gesslbauer, M.K. Sixt, H. Strobl, European Journal of Immunology 44 (2014) 553–560.
LibreCat: https://research-explorer.app.ist.ac.at/record/1910
DOI: 10.1002/eji.201343681

New paradigms in the establishment and maintenance of gradients during directed cell migration
R. Majumdar, M.K. Sixt, C. Parent, Current Opinion in Cell Biology 30 (2014) 33–40.
LibreCat: https://research-explorer.app.ist.ac.at/record/2158
DOI: 10.1016/j.ceb.2014.05.010
PMID: 24959970

Blood vessels pattern heparan sulfate gradients between their apical and basolateral aspects
L. Stoler Barak, C. Moussion, E. Shezen, M. Hatzav, M.K. Sixt, R. Alon, PLoS One 9 (2014).
LibreCat: https://research-explorer.app.ist.ac.at/record/2214
DOI: 10.1371/journal.pone.0085699

A miR-155-dependent microRNA hierarchy in dendritic cell maturation and macrophage activation
A. Dueck, A. Eichner, M.K. Sixt, G. Meister, FEBS Letters 588 (2014) 632–640.
LibreCat: https://research-explorer.app.ist.ac.at/record/2242
DOI: 10.1016/j.febslet.2014.01.009

A conduit to amplify innate immunity
C. Moussion, M.K. Sixt, Immunity 38 (2013) 853–854.
LibreCat: https://research-explorer.app.ist.ac.at/record/2830
DOI: 10.1016/j.immuni.2013.05.005

Interstitial dendritic cell guidance by haptotactic chemokine gradients
M. Weber, R. Hauschild, J. Schwarz, C. Moussion, I. de Vries, D. Legler, S. Luther, M.T. Bollenbach, M.K. Sixt, Science 339 (2013) 328–332.
LibreCat: https://research-explorer.app.ist.ac.at/record/2839
DOI: 10.1126/science.1228456

Thymic medullar conduits-associated podoplanin promotes natural regulatory T cells
E. Fuertbauer, J. Zaujec, P. Uhrin, I. Raab, M. Weber, H. Schachner, M. Bauer, G. Schütz, B. Binder, M.K. Sixt, D. Kerjaschki, H. Stockinger, Immunology Letters 154 (2013) 31–41.
LibreCat: https://research-explorer.app.ist.ac.at/record/522
DOI: 10.1016/j.imlet.2013.07.007

Tissue inducible Lifeact expression allows visualization of actin dynamics in vivo and ex vivo
H. Schachtner, A. Li, D. Stevenson, S. Calaminus, S. Thomas, S. Watson, M.K. Sixt, R. Wedlich Söldner, D. Strathdee, L. Machesky, European Journal of Cell Biology 91 (2012) 923–929.
LibreCat: https://research-explorer.app.ist.ac.at/record/3158
DOI: 10.1016/j.ejcb.2012.04.002
PMID: 22658956

Cell migration: Fibroblasts find a new way to get ahead
M.K. Sixt, Journal of Cell Biology 197 (2012) 347–349.
LibreCat: https://research-explorer.app.ist.ac.at/record/506
DOI: 10.1083/jcb.201204039

The role of chemotactic gradients in dendritic cell migration
K. Schumann, The Role of Chemotactic Gradients in Dendritic Cell Migration, IST Austria, 2011.
LibreCat: https://research-explorer.app.ist.ac.at/record/3275

Cells on the move in Philadelphia
M.K. Sixt, C. Parent, Molecular Biology and Evolution 22 (2011) 724.
LibreCat: https://research-explorer.app.ist.ac.at/record/3371
DOI: 10.1091/mbc.E10-12-0958

Interstitial locomotion of leukocytes
M.K. Sixt, Immunology Letters 138 (2011) 32–34.
LibreCat: https://research-explorer.app.ist.ac.at/record/3385
DOI: 10.1016/j.imlet.2011.02.013

In vivo analysis of uropod function during physiological T cell trafficking
S. Soriano, M. Hons, K. Schumann, V. Kumar, T. Dennier, R. Lyck, M.K. Sixt, J. Stein, Journal of Immunology 187 (2011) 2356–2364.
LibreCat: https://research-explorer.app.ist.ac.at/record/3392
DOI: 10.4049/jimmunol.1100935

Setting the clock for recirculating lymphocytes
A. Eichner, M.K. Sixt, Science Signaling 4 (2011).
LibreCat: https://research-explorer.app.ist.ac.at/record/491
DOI: 10.1126/scisignal.2002617

CAMT is a novel tumour suppressor regulated by miR-9/9 * in glioblastoma stem cells
D. Schraivogel, L. Weinmann, D. Beier, G. Tabatabai, A. Eichner, J. Zhu, M. Anton, M.K. Sixt, M. Weller, C. Beier, G. Meister, EMBO Journal 30 (2011) 4309–4322.
LibreCat: https://research-explorer.app.ist.ac.at/record/518
DOI: 10.1038/emboj.2011.301
PMID: 21857646

In vitro analysis of chemotactic leukocyte migration in 3D environments
M.K. Sixt, T. Lämmermann, Cell Migration 769 (2011) 149–165.
LibreCat: https://research-explorer.app.ist.ac.at/record/3505
DOI: 10.1007/978-1-61779-207-6_11

Breaching multiple barriers: leukocyte motility through venular walls and the interstitium
S. Nourshargh, P. Hordijk, M.K. Sixt, Nature Reviews Molecular Cell Biology 11 (2010) 366–378.
LibreCat: https://research-explorer.app.ist.ac.at/record/3956
DOI: 10.1038/nrm2889

Lifeact mice for studying F-actin dynamics
J. Riedl, K. Flynn, A. Raducanu, F.R. Gärtner, G. Beck, M. Bosl, F. Bradke, S. Massberg, A. Aszodi, M.K. Sixt, R. Wedlich Söldner, Nature Methods 7 (2010) 168–169.
LibreCat: https://research-explorer.app.ist.ac.at/record/3957
DOI: 10.1038/nmeth0310-168

Extracellular matrix in multiple sclerosis lesions: fibrillar collagens, biglycan and decorin are upregulated and associated with infiltrating immune cells
H. Mohan, M. Krumbholz, R. Sharma, S. Eisele, A. Junker, M.K. Sixt, J. Newcombe, H. Wekerle, R. Hohlfeld, H. Lassmann, E. Meinl, Brain Pathology 20 (2010) 966–975.
LibreCat: https://research-explorer.app.ist.ac.at/record/3958
DOI: 10.1111/j.1750-3639.2010.00399.x

Immobilized chemokine fields and soluble chemokine gradients cooperatively shape migration patterns of dendritic cells
K. Schumann, T. Lämmermann, M. Bruckner, D. Legler, J. Polleux, J. Spatz, G. Schuler, R. Förster, M. Lutz, L. Sorokin, M.K. Sixt, Immunity 32 (2010) 703–713.
LibreCat: https://research-explorer.app.ist.ac.at/record/3959
DOI: 10.1016/j.immuni.2010.04.017

MEK signalling tunes actin treadmilling for interstitial lymphocyte migration
M. Weber, M.K. Sixt, EMBO Journal 29 (2010) 2861–2863.
LibreCat: https://research-explorer.app.ist.ac.at/record/3960
DOI: 10.1038/emboj.2010.183

Mechanisms of force generation and force transmission during interstitial leukocyte migration
J. Renkawitz, M.K. Sixt, EMBO Reports 11 (2010) 744–750.
LibreCat: https://research-explorer.app.ist.ac.at/record/3961
DOI: 10.1038/embor.2010.147

Analogies in the evolution of individual and social immunity
S. Cremer, M.K. Sixt, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 364 (2009) 129–142.
LibreCat: https://research-explorer.app.ist.ac.at/record/3946
DOI: 10.1098/rstb.2008.0166

Cd-dependent leading edge coordination is essential for interstitial dendritic cell migration (Plenary Paper)
T. Lämmermann, J. Renkawitz, X. Wu, K. Hirsch, C. Brakebusch, M.K. Sixt, Blood 113 (2009) 5703–5710.
LibreCat: https://research-explorer.app.ist.ac.at/record/3947
DOI: 10.1182/blood-2008-11-191882

;21 integrins differentially control extravasation of inflammatory cell subsets into the CNS during autoimmunity
M. Bauer, C. Brakebusch, C. Coisne, M.K. Sixt, H. Wekerle, B. Engelhardt, R. Fässler, PNAS 106 (2009) 1920–1925.
LibreCat: https://research-explorer.app.ist.ac.at/record/3948
DOI: 10.1073/pnas.0808909106

Cytohesin-1 controls the activation of RhoA and modulates integrin-dependent adhesion and migration of dendritic cells
T. Quast, B. Tappertzhofen, C. Schild, J. Grell, N. Czeloth, R. Förster, R. Alon, L. Fraemohs, K. Dreck, C. Weber, T. Lämmermann, M.K. Sixt, W. Kolanus, Blood 113 (2009) 5801–5810.
LibreCat: https://research-explorer.app.ist.ac.at/record/3949
DOI: 10.1182/blood-2008-08-176123

Kindlin-3 is required for ;22 integrin-mediated leukocyte adhesion to endothelial cells
M. Moser, M. Bauer, S. Schmid, R. Ruppert, S. Schmidt, M.K. Sixt, H. Wang, M. Sperandio, R. Fässler, Nature Medicine 15 (2009) 300–305.
LibreCat: https://research-explorer.app.ist.ac.at/record/3950
DOI: 10.1038/nm.1921

Mechanical modes of ‘amoeboid’ cell migration
T. Lämmermann, M.K. Sixt, Current Opinion in Cell Biology 21 (2009) 636–644.
LibreCat: https://research-explorer.app.ist.ac.at/record/3951
DOI: 10.1016/j.ceb.2009.05.003

A fundamental role of mAb in neutrophils: impact on ;2(2) integrin-mediated phagocytosis and adhesion in vivo
J. Schymeinsky, R. Gerstl, I. Mannigel, K. Niedung, D. Frommhold, K. Panthel, J. Heesemann, M.K. Sixt, T. Quast, W. Kolanus, A. Mocsai, J. Wienands, M. Sperandio, B. Walzog, Blood 114 (2009) 4209–4220.
LibreCat: https://research-explorer.app.ist.ac.at/record/3952
DOI: 10.1182/blood-2009-02-206169

The sphingosine 1-phosphate receptor agonist F potently inhibits regulatory T cell proliferation in vitro and in vivo
A. Wolf, K. Eller, R. Zeiser, C. Dürr, U. Gerlach, M.K. Sixt, L. Markut, G. Gastl, A. Rosenkranz, D. Wolf, Journal of Immunology 183 (2009) 3751–3760.
LibreCat: https://research-explorer.app.ist.ac.at/record/3953
DOI: 10.4049/jimmunol.0901011

Adaptive force transmission in amoeboid cell migration
J. Renkawitz, K. Schumann, M. Weber, T. Lämmermann, H. Pflicke, M. Piel, J. Polleux, J. Spatz, M.K. Sixt, Nature Cell Biology 11 (2009) 1438–1443.
LibreCat: https://research-explorer.app.ist.ac.at/record/3954
DOI: 10.1038/ncb1992

Preformed portals facilitate dendritic cell entry into afferent lymphatic vessels
H. Pflicke, M.K. Sixt, The Journal of Experimental Medicine 206 (2009) 2925–2935.
LibreCat: https://research-explorer.app.ist.ac.at/record/3955
DOI: 10.1084/jem.20091739